The sugarcane crop growth simulation model was calibrated and validated in Eastern Uttar Pradesh (UP) region of Indo-Gangetic Plains of India using 12 years field experiment data conducted in several places. The results reveal that the CANEGRO Sugarcane model satisfactorily simulated the potential growth and yield of sugarcane crop. The model simulates the stalk height, stalk fresh mass and sucrose yield within ±15 % of range in comparison to the observed values. Therefore the validated CANEGRO Sugarcane model can be further used for applications such as prediction of crop growth, phenology, water management, potential and actual yields, performance of sugarcane under climate variability and change scenarios etc. The model may also be used to improve and evaluate the current practices of sugarcane growth management to achieve enhanced cane production and sugar recovery.