The DSSAT CANEGRO model was calibrated and validated using field experimental data (1997- 2013) from four locations of north Indian region.The genetic coefficients for 10 cultivars of sugarcane were estimated.R2 obtained between measured and simulated stalk yield was 0.69 with the nRMSE (7.50%) and D-index (0.91) and R2 between measured and simulated sucrose mass was 0.57 with the nRMSE(11.75%) and D-index (0.85). The model underestimated both the stalk fresh mass as well as sucrose mass by 2 and 6 per cent only, respectively.Hence,the CANEGRO model can be used to simulate the phenology and yield attributes of sugarcane cultivars of north India particularly of Uttar Pradesh region. The model can also be used to evaluate and improve the present practices of sugarcane crop management to obtain increased cane production and sugar recovery.