CERES wheat and CROPGRO urd model were used for sequential simulation to examine the stability of urd-wheat crop rotation as influenced by the interaction between environment and nutrient status. The results revealed that the CERES wheat and CROPGRO urd model satisfactorily simulated the growth and yield in sequential run. Therefore, the validated model can be further used for applications such as sequential study, crop growth, phenology, potential and actual yields etc. The effects of one crop on soil, water, and nutrient status are carried over to the next crop in the sequence or rotation. These sequences can be efficiently studied by the sequence analysisprogram of DSSAT.